Medical Hypotheses

Medical Hypotheses (2006) 66, 466472 http://intl.elsevierhealth.com/journals/mehy Epilepsy and hemicrania: The dopamine hypotheses Shih-Cheng Chen * Department of Neurology, Tri-Service overflowing general Hospital, National Defense Medical Center, No. 325, particle 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan, ROC subscribe to 22 folk 2005; accepted 27 September 2005 digest hemicrania and epilepsy argon some(prenominal)(prenominal) chronic perennial dis ordains with paroxysmal attacks. They as well as sh ar some standardised risk factors, symptoms, and prophylactic device medications. dopamine has long been postulated to be involved in the pathophysiology of migraine and epileptogenesis, by many supporting evidences. However, the agency of dopamine is dumb controversial till now. A lack of a all-round(prenominal) hypothetical model may be one of the reasons. dopamine hypothesis is not a cutting term, but it is proposed to explain the pathophysi ology and the associated phenomena of these disorders. The hypotheses suggest that, in migraine, there is a low dopamine tone, while there is a advanced state of dopamine in generalized epilepsy. But the day-by-day attacks of headaches and seizures maybe both(prenominal) due to a fall in dopamine activity. Dopamine therefore plays a key role in the gene linkage of neuroendocrine, autonomic system and nervous activity.

Dopamine agonist is also implied in prophylaxis and neuroprotection in both disorders. c 2005 Elsevier Ltd. All rights reserved.  Introduction Migraine and epilepsy are categorize as paroxys mal disorders. They are both chronic recurre! nt disorders with episodic attacks. Besides the two disorders have several similarities and associations, which are listed as follows [1]: 1. They are both conglomerate disorders with periodic personality in common. 2. The attacks of headaches and seizures tend to go by typical courses, which may include prodromal phase, aura, and postdrome. 3. There are several similar risk factors, such as stress, alcoholic drink consumption, period cycle in...If you want to get a full essay, order it on our website: BestEssayCheap.com

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